Volume 2, Number 1, April-May-June 2009

Prescribing for patients with chronic kidney disease
Professor Michael Kirby

Chronic kidney disease (CKD) affects renal drug elimination and other important processes involved in drug disposition, including absorption, drug distribution and non-renal clearance. As a result, the reduced renal excretion of a drug or its metabolites can cause toxicity and the sensitivity to some drugs is increased even if elimination is unimpaired.

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